ALPL Antibody - middle region
Catalog Number:
ASB-ARP97914_P050
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| Article Name: | ALPL Antibody - middle region |
| Biozol Catalog Number: | ASB-ARP97914_P050 |
| Supplier Catalog Number: | ARP97914_P050 |
| Alternative Catalog Number: | ASB-ARP97914_P050-25UL,ASB-ARP97914_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human ALPL |
| Alternative Names: | HOPS, TNAP, TNALP, APTNAP, TNSALP, AP-TNAP |
| This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. |
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