SLC27A2 Polyclonal Antibody (Human)
Catalog Number:
ASB-ATP00016_T100
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| Article Name: | SLC27A2 Polyclonal Antibody (Human) |
| Biozol Catalog Number: | ASB-ATP00016_T100 |
| Supplier Catalog Number: | ATP00016_T100 |
| Alternative Catalog Number: | ASB-ATP00016_T100-100UL |
| Manufacturer: | Aviva |
| Category: | Proteine/Peptide |
| Application: | ICC, WB |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human SLC27A2 aa 481-620 |
| Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:20530735, PubMed:22022213, PubMed:24269233, PubMed:10198260, PubMed:10749848, PubMed:11980911). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:20530735, PubMed:22022213, PubMed:24269233, PubMed:10198260, PubMed:10749848, PubMed:11980911). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:20530735). Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260). May contribute to the synthesis of sphingosine-1-phosphate (PubMed:24269233). Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911). In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911). However, it is not critical for THCA activation and bile synthesis in vivo (PubMed:20530735). |
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