NLRC4 Antibody - C-terminal region
Catalog Number:
ASB-AVARP00019_P050
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| Article Name: | NLRC4 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-AVARP00019_P050 |
| Supplier Catalog Number: | AVARP00019_P050 |
| Alternative Catalog Number: | ASB-AVARP00019_P050-25UL,ASB-AVARP00019_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Guinea pig, Human, Mouse, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human NLRC4 |
| Alternative Names: | CLAN, IPAF, AIFEC, CLAN1, CLANA, CLANB, CLANC, CLAND, FCAS4, CARD12, CLR2.1 |
| In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1, NOD1, and NOD2. These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis. |
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