CASP3 Antibody - N-terminal region
Catalog Number:
ASB-AVARP00021_T100
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| Article Name: | CASP3 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-AVARP00021_T100 |
| Supplier Catalog Number: | AVARP00021_T100 |
| Alternative Catalog Number: | ASB-AVARP00021_T100-25UL,ASB-AVARP00021_T100-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Bovine, Canine, Equine, Guinea pig, Human, Porcine, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human CASP3 |
| Alternative Names: | CPP32, SCA-1, CPP32B |
| CASP3 is a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimers disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. |
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