TNFRSF1A Antibody - N-terminal region
Catalog Number:
ASB-AVARP00034_P050
- Images (7)
| Article Name: | TNFRSF1A Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-AVARP00034_P050 |
| Supplier Catalog Number: | AVARP00034_P050 |
| Alternative Catalog Number: | ASB-AVARP00034_P050-25UL,ASB-AVARP00034_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IF, WB |
| Species Reactivity: | Guinea pig, Human, Mouse |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human TNFRSF1A |
| Alternative Names: | FPF, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55 |
| TNFRSF1A is the receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNFRSF1A contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
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Immunofluorescent TNFRSF1A detection in human lymphocytes (green fluorescence). Nuclei were stained with DAPI (blue fluorescence). Working dilution 5-10 ug/ml |
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WB Suggested Anti-TNFRSF1A Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: DU145 cell lysateTNFRSF1A is supported by BioGPS gene expression data to be expressed in DU145 |
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Host: Rabbit Target: TNFRSF1A Positive control (+): THP-1 (N30) Negative control (-): SH-SY5Y (N19) Antibody concentration: 1ug/ml |
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Host: Rabbit Target Name: TNFRSF1A Sample Tissue: Human Jurkat Whole Cell Antibody Dilution: 1ug/ml |
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25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. The protein is processed to ~48 kDa, a smaller isoform of 24 kDa also contains the peptide sequence, and the protein may also be glycosylated. |
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Host: Rabbit Target Name: TNFRSF1A Sample Tissue: Human A549 Whole Cell Antibody Dilution: 1ug/ml |
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TNFRSF1A antibody - N-terminal region (AVARP00034_P050) in Human DU145 using Western Blot |
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