FADD Antibody - C-terminal region
Catalog Number:
ASB-AVARP01012_P050
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| Article Name: | FADD Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-AVARP01012_P050 |
| Supplier Catalog Number: | AVARP01012_P050 |
| Alternative Catalog Number: | ASB-AVARP01012_P050-25UL,ASB-AVARP01012_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C terminal region of human FADD |
| Alternative Names: | GIG3, MORT1 |
| The protein encoded by FADD is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. |
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