CDC42 Antibody - N-terminal region
Catalog Number:
ASB-AVARP01017_P050
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| Article Name: | CDC42 Antibody - N-terminal region |
| Biozol Catalog Number: | ASB-AVARP01017_P050 |
| Supplier Catalog Number: | AVARP01017_P050 |
| Alternative Catalog Number: | ASB-AVARP01017_P050-25UL,ASB-AVARP01017_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | IHC, WB |
| Species Reactivity: | Canine, Rabbit |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human CDC42 |
| Alternative Names: | TKS, G25K, CDC42Hs |
| CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. |
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