TRADD Antibody - middle region
Catalog Number:
ASB-AVARP02012_P050
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| Article Name: | TRADD Antibody - middle region |
| Biozol Catalog Number: | ASB-AVARP02012_P050 |
| Supplier Catalog Number: | AVARP02012_P050 |
| Alternative Catalog Number: | ASB-AVARP02012_P050-25UL,ASB-AVARP02012_P050-100UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Canine, Equine, Human |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human TRADD |
| Alternative Names: | Hs.89862 |
| TRADD is the adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
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