Leo1 Antibody - C-terminal region
Catalog Number:
ASB-OAAB19070
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| Article Name: | Leo1 Antibody - C-terminal region |
| Biozol Catalog Number: | ASB-OAAB19070 |
| Supplier Catalog Number: | OAAB19070 |
| Alternative Catalog Number: | ASB-OAAB19070-400UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | This Mouse Leo1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 616-650 amino acids from the C-terminal region of Mouse Leo1. |
| Alternative Names: | Gm185 |
| Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and Ser-2- and Ser-5-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 Lys- 4 (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of Lys-120 of histone H2B (H2BK120ub1), UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3 end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity). |
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