RICTOR Antibody - middle region
Catalog Number:
ASB-OAAB19339
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| Article Name: | RICTOR Antibody - middle region |
| Biozol Catalog Number: | ASB-OAAB19339 |
| Supplier Catalog Number: | OAAB19339 |
| Alternative Catalog Number: | ASB-OAAB19339-400UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Human |
| Immunogen: | This RICTOR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1068-1102 amino acids from the Central region of human RICTOR. |
| Alternative Names: | PIA, AVO3, hAVO3 |
| Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657. Plays an essential role in embryonic growth and development. |
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