UNC5B Antibody - middle region
Catalog Number:
ASB-OAAB19370
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| Article Name: | UNC5B Antibody - middle region |
| Biozol Catalog Number: | ASB-OAAB19370 |
| Supplier Catalog Number: | OAAB19370 |
| Alternative Catalog Number: | ASB-OAAB19370-400UL |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | WB |
| Species Reactivity: | Mouse, Rat |
| Immunogen: | This UNC5B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 507-541 amino acids from the Central region of human UNC5B. |
| Alternative Names: | UNC5H2, p53RDL1 |
| Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. |
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