The antiserum was produced against synthesized peptide derived from human MOL1A.
Alternative Names:
MATS2,MOB kinase activator 1B,mob1 homolog 1A,MOB1 Mps One Binder homolog B,MOB1, Mps One Binder kinase activator-like 1A,mob1A,Mob1B,MOB4A,MOBKL1A,mps one binder kinase activator-like 1A.
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
