The antiserum was produced against synthesized peptide derived from human Histone H2A around the acetylated site of Lys5.
Alternative Names:
H2A histone family member Z,H2A.z,H2A.Z-1,H2A/z,H2AFZ,H2AZ,H2AZ histone,histone H2A.Z.
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.