Anti-SOCS-5 Polyclonal Antibody, Rabbit
Catalog Number:
ASB-OAAI00007
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| Article Name: | Anti-SOCS-5 Polyclonal Antibody, Rabbit |
| Biozol Catalog Number: | ASB-OAAI00007 |
| Supplier Catalog Number: | OAAI00007 |
| Alternative Catalog Number: | ASB-OAAI00007-100UG |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, FC, IHC, IP, WB |
| Species Reactivity: | Human, Mouse |
| Immunogen: | A synthetic peptide corresponding to the C-terminus of SOCS-5 protein from human, mouse and rat origins |
| Alternative Names: | CIS6,CIS-6,Cish5,CISH6,cytokine-inducible SH2 protein 6,cytokine-inducible SH2-containing protein 5,SOCS-5,suppressor of cytokine signaling 5. |
| Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways which are suppressed by other transcriptional factors. Proteins that mediate these signals from the cell surface to the nucleus include JAKs and STATs, while SOCS (Suppressor of cytokine signaling) proteins inhibit those signaling. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C terminal motif named the SOCS box. SOCS5 regulates IL-4 signaling throµgh JAK1 negatively. |
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