Anti-TGF- Beta R1 Polyclonal Antibody, Rabbit
Catalog Number:
ASB-OAAI00094
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| Article Name: | Anti-TGF- Beta R1 Polyclonal Antibody, Rabbit |
| Biozol Catalog Number: | ASB-OAAI00094 |
| Supplier Catalog Number: | OAAI00094 |
| Alternative Catalog Number: | ASB-OAAI00094-100UG |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, FC, IHC, IP, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthetic peptide of human TGFbR1 |
| Alternative Names: | AAT5,activin A receptor type II-like kinase, 53kDa,activin A receptor type II-like protein kinase of 53kD,activin receptor-like kinase 5,ACVRLK4,ALK5,ALK-5,ESS1,LDS1,LDS1A,LDS2A,MSSE,mutant transforming growth factor beta receptor I,serine/threonine-protein kinase receptor R4,SKR4,tbetaR-I,TBR-i,TBRI,TGF-beta receptor type-1,TGFR-1,transforming growth factor beta receptor I,transforming growth factor-beta receptor type I. |
| Transforming growth factor beta isoforms (TGF-beta1, 2, 3) play vital roles in regulating cellular growth and differentiation, and they signal throµgh a highly restricted subset of receptors known as TGF-beta type I receptor (TbetaR-I) and TGF-beta type II receptor(TbetaR-II). TGF-betas specificity for TbetaR-I has been proposed to arise from its pre-helix extension, a five-residue loop that binds in the cleft between TGF-beta and TbetaR-II. TGF-beta binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain, which requires both its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta, and receptor II requires receptor I to signal. Mutations in TbetaR-I and TbetaR-II gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). |
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