Anti-C-erbB-2/HER-2 Antibody, IgG1, Clone: [S495], Mouse, Monoclonal
Catalog Number:
ASB-OAAI00099
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| Article Name: | Anti-C-erbB-2/HER-2 Antibody, IgG1, Clone: [S495], Mouse, Monoclonal |
| Biozol Catalog Number: | ASB-OAAI00099 |
| Supplier Catalog Number: | OAAI00099 |
| Alternative Catalog Number: | ASB-OAAI00099-100UG |
| Manufacturer: | Aviva |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | ELISA, FC, IHC, IP, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | A synthetic peptide corresponding to the C-terminus of Her2 protein. This sequence is identical in human, mouse, and ra |
| Alternative Names: | CD340,c-erb B2/neu protein,HER2,HER-2,HER-2/neu,herstatin,human epidermal growth factor receptor 2,metastatic lymph node gene 19 protein,MLN 19,NEU,neuro/glioblastoma derived oncogene homolog,neuroblastoma/glioblastoma derived oncogene homolog,NGL,proto-oncogene c-ErbB-2,proto-oncogene Neu,receptor tyrosine-protein kinase erbB-2,TKR1,tyrosine kinase-type cell surface receptor HER2,v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2,v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2,v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog,VSCN2. |
| Oncoprotein Her-2/Neu/ c-erbB-2 belongs to one of the four members of the ErbB receptor family. They are transmembrane receptor-like tyrosine kinases which can be autophosphorylated without ligand binding process when it is overexpressed in breast cancers. Her2 is an important biomarker in breast cancer diagnosis. The antibodies/ heregulin can suppress phosphorylation of HER2 on tyrosine Y1248. Endogenous anti-HER2 antibodies can effectively suppress HER2 kinase activity and downstream signaling to inhibit the transformed phenotype of HER2-expressing tumor cells. Thus, anti-Her2 antibodies have been used widely in the treatment of the breast cancer and other carcinomas. |
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