Bovine, Canine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat, Sheep
Immunogen:
KLH conjugated synthetic peptide derived from human CCL5
Conjugation:
Unconjugated
Alternative Names:
beta-chemokine RANTES,C-C motif chemokine 5,chemokine (C-C motif) ligand 5,D17S136E,eoCP,eosinophil chemotactic cytokine,RANTES,regulated upon activation, normally T-expressed, and presumably secreted,SCYA5,SISd,SIS-delta,small inducible cytokine subfamily A (Cys-Cys), member 5,Small-inducible cytokine A5,T cell-specific protein P228,T-cell specific protein p288,T-cell-specific protein RANTES,TCP228.
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218). May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).
