MKI67 Antibody (OABF00917-100UL), Unconjugated, Rabbit, Polyclonal

Catalog Number: ASB-OABF00917
Article Name: MKI67 Antibody (OABF00917-100UL), Unconjugated, Rabbit, Polyclonal
Biozol Catalog Number: ASB-OABF00917
Supplier Catalog Number: OABF00917
Alternative Catalog Number: ASB-OABF00917-100UL
Manufacturer: Aviva
Host: Rabbit
Category: Antikörper
Application: ELISA, IF, IHC-P
Species Reactivity: Human, Mouse, Rat
Immunogen: KLH conjugated synthetic peptide derived from human Ki67
Conjugation: Unconjugated
Alternative Names: antigen identified by monoclonal antibody Ki-67,antigen Ki67,KIA,MIB-,MIB-1,Molecular Immunology Borstel antibody 1,PPP1R105,proliferation marker protein Ki-67,proliferation-related Ki-67 antigen,protein phosphatase 1, regulatory subunit 105.
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
Clonality: Polyclonal
Concentration: 1 ug/ul
NCBI: 4288
Form: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.