beta-trace protein,cerebrin-28,glutathione-independent PGD synthase,glutathione-independent PGD synthetase,lipocalin-type prostaglandin D synthase,Lipocalin-type prostaglandin-D synthase,LPGDS,L-PGDS,PDS,PGD2,PGD2 synthase,PGDS,PGDS2,prostaglandin D synthase,prostaglandin D2 synthase 21kDa (brain),Prostaglandin-D2 synthase,prostaglandin-H2 D-isomerase,testis tissue sperm-binding protein Li 63n.
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
