CTHBP,cytosolic thyroid hormone-binding protein,epididymis secretory protein Li 30,HEL-S-30,OIP3,OPA-interacting protein 3,p58,PK, muscle type,PK3,PKM2,pyruvate kinase 2/3,pyruvate kinase isozymes M1/M2,pyruvate kinase muscle isozyme,pyruvate kinase PKM,pyruvate kinase, muscle,TCB,THBP1,thyroid hormone-binding protein 1,thyroid hormone-binding protein, cytosolic,tumor M2-PK.
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
