PLA2G2A Antibody

Product Overview

• Article Name: PLA2G2A Antibody
• Biozol Catalog Number: ASB-OACD06557
• Supplier Catalog Number: OACD06557
• Alternative Catalog Number: ASB-OACD06557-100UL,ASB-OACD06557-1ML
• Manufacturer: Aviva
• Host: Rabbit
• Category: Proteine/Peptide
• Application: ICC, IHC, IP, WB
• Species Reactivity: Human
• Immunogen: Range: Asn21 - Cys144
• Alternative Names: GIIC sPLA2,group IIA phospholipase A2,MOM1,non-pancreatic secretory phospholipase A2,NPS-PLA2,phosphatidylcholine 2-acylhydrolase 2A,phospholipase A2, group IIA (platelets, synovial fluid),phospholipase A2, membrane associated,PLA2,PLA2B,PLA2L,PLA2S,PLAS1,sPLA2.

Product Description

Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).

Product Properties

• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Molecular Weight: 16 kDa
• NCBI: 5320
• Form: Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.