Nr1,Nr1c2,NUC,NUC1,NUC-1,nuclear hormone receptor 1,nuclear receptor subfamily 1 group C member 2,P,Peroxisome proliferator-activated receptor beta,peroxisome proliferator-activated receptor delta,Ppa,PPAR,PPAR[b],Pparb,Pparb/d,PPAR-beta,PPARdelta,PPAR-delta,PPARdelta/beta.
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity).
