grpE Antibody, Rabbit, Polyclonal
Catalog Number:
ASB-OAED00141
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| Article Name: | grpE Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ASB-OAED00141 |
| Supplier Catalog Number: | OAED00141 |
| Alternative Catalog Number: | ASB-OAED00141-1MG |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Species Reactivity: | E. coli |
| Immunogen: | Purified E. coli GrpE. |
| Alternative Names: | b2614,ECK2610,Heat shock protein B25.3,HSP24,HSP-70 cofactor,nucleotide exchange factor GrpE. |
| Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ, upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK, ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. |
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