HSPA5 Antibody, Rabbit, Polyclonal
Catalog Number:
ASB-OAED00189
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| Article Name: | HSPA5 Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ASB-OAED00189 |
| Supplier Catalog Number: | OAED00189 |
| Alternative Catalog Number: | ASB-OAED00189-50UG |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Species Reactivity: | Bovine, Fungi, Hamster, Monkey, Mouse, Rabbit, Rat, Xenopus |
| Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of rat Grp78 (BiP). The sequence is completely conserved in mouse and hamster. |
| Alternative Names: | 78 kDa glucose-regulated protein,binding-immunoglobulin protein,BIP,endoplasmic reticulum chaperone BiP,GRP 78,GRP78,GRP-78,heat shock 70 kDa protein 5,heat shock 70kD protein 5,heat shock 70kDa protein 5 (glucose-regulated protein),heat shock protein 5,heat shock protein 70 family protein 5,heat shock protein family A member 5,HSP70 family protein 5,immunoglobulin heavy chain-binding protein,steroidogenesis-activator polypeptide. |
| Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). |
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