CD300 antigen-like family member A,CD300a antigen,CLM-8,CMRF35H,CMRF35-H,CMRF-35H,CMRF35H leukocyte immunoglobulin-like receptor,CMRF35H9,CMRF35-H9,CMRF-35-H9,CMRF35-like molecule 8,IGSF12,immunoglobulin superfamily member 12,inhibitory receptor protein 60,IRC1,IRC1/IRC2,IRC2,IRp60,leukocyte membrane antigen,NK inhibitory receptor.
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).
The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.