AI172977,al,alpha IIb,alphaIIb,CD41,CD41B,Gp,GP IIb,GPalpha IIb,GpIIb,integrin alpha-IIb,platelet glycoprotein IIb of IIb/II Ia complex,platelet membrane glycoprotein IIb.
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
