Leukocytes of a patient suffering from LGL Type Leukaemia.
Conjugation:
APC
Alternative Names:
CD44 antigen,CDW44,cell surface glycoprotein CD44,chondroitin sulfate proteoglycan 8,CSPG8,ECMR-III,epican,extracellular matrix receptor III,GP90 lymphocyte homing/adhesion receptor,HCELL,hematopoietic cell E- and L-selectin ligand,heparan sulfate proteoglycan,Hermes antigen,homing function and Indian blood group system,HUTCH-I,hyaluronate receptor,IN,Indian blood group antigen,LHR,MC56,MDU2,MDU3,MIC4,Pgp1,phagocytic glycoprotein 1,Phagocytic glycoprotein I,soluble CD44.
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9, the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity).
The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
