B220,CD45,CD45 antigen,CD45R,GP180,LCA,L-CA,Leukocyte common antigen,LY5,protein tyrosine phosphatase, receptor type, c polypeptide,receptor-type tyrosine-protein phosphatase C,T200,T200 glycoprotein,T200 leukocyte common antigen.
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
