Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.
Clonality:
Monoclonal
Concentration:
1 mg/ml
Clone Designation:
[1E12E10]
Isotype:
IgG1
Buffer:
PBS, 0.1% Sodium Azide, 1% BSA
Form:
Liquid PBS with 0.1% sodium azide and 1% BSA
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