MADD antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human MADD. The immunogen is located within the last 50 amino acids of MADD.
Conjugation:
Unconjugated
Alternative Names:
DEEAH,DENN,differentially expressed in normal and neoplastic cells,IG20,insulinoma glucagonoma clone 20,MAP kinase-activating death domain protein,NEDDISH,Rab3 GDP/GTP exchange factor,rab3 GDP/GTP exchange protein,RAB3GEP,RabGEF.
Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis), isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
