FLIP antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human FLIP. The sequence is identical in all FLIP splice variants. The immunogen is located within the first 50 amino acids of FLIP.
Conjugation:
Unconjugated
Alternative Names:
CASH,CASP8 and FADD-like apoptosis regulator,CASP8AP1,caspase homolog,caspase-eight-related protein,caspase-like apoptosis regulatory protein,caspase-related inducer of apoptosis,Casper,cellular FLICE-like inhibitory protein,cFLIP,c-FLIP,c-FLIPL,c-FLIPR,c-FLIPS,CLARP,FADD-like antiapoptotic molecule 1,FLAME,FLAME1,FLAME-1,FLIP,I-FLICE,inhibitor of FLICE,MACH-related inducer of toxicity,MRIT,testis secretory sperm-binding protein Li 233m,Usurpin,usurpin beta.
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
