FLIP antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FLIP. The immunogen is located within amino acids 180 - 230 of FLIP.
Conjugation:
Unconjugated
Alternative Names:
CASH,CASP8 and FADD-like apoptosis regulator,CASP8AP1,caspase homolog,caspase-eight-related protein,caspase-like apoptosis regulatory protein,caspase-related inducer of apoptosis,Casper,cellular FLICE-like inhibitory protein,cFLIP,c-FLIP,c-FLIPL,c-FLIPR,c-FLIPS,CLARP,FADD-like antiapoptotic molecule 1,FLAME,FLAME1,FLAME-1,FLIP,I-FLICE,inhibitor of FLICE,MACH-related inducer of toxicity,MRIT,testis secretory sperm-binding protein Li 233m,Usurpin,usurpin beta.
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
