Toso antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human Toso. The immunogen is located within the first 50 amino acids of Toso.
Conjugation:
Unconjugated
Alternative Names:
FAIM3,fas apoptotic inhibitory molecule 3,Fc mu receptor,IgM Fc fragment receptor,IgM Fc receptor,immunoglobulin mu Fc receptor,regulator of Fas-induced apoptosis Toso,TOSO.
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
