Anti-RIP3 antibody (2283) was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of murine RIP3. The immunogen is located within the last 50 amino acids of RIP3.
Conjugation:
Unconjugated
Alternative Names:
2610528K09Rik,AW107945,mRIP3,R,receptor interacting protein 3,Receptor-interacting protein 3,receptor-interacting serine/threonine-protein kinase 3,Rip3,RIP-3,RIP-like protein kinase 3.
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Clonality:
Polyclonal
Concentration:
1 mg/ml
Molecular Weight:
Predicted: 53kD for mouse RIP3 and 57kD for human RIP3 Observed: 53kD for mouse RIP3 and 57kD for human RIP3
