p53R2 antibody was raised against a 16 amino acid peptide near the amino terminus of human p53R2. The immunogen is located within the first 50 amino acids of p53R2.
Conjugation:
Unconjugated
Alternative Names:
MTDPS8A,MTDPS8B,p53-inducible ribonucleotide reductase small subunit 2 homolog,p53-inducible ribonucleotide reductase small subunit 2 short form beta,p53-inducible ribonucleotide reductase small subunit 2-like protein,P53R2,ribonucleoside-diphosphate reductase subunit M2 B,ribonucleotide reductase M2 B (TP53 inducible),TP53-inducible ribonucleotide reductase M2 B.
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
