AID antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human AID. The immunogen is located within the last 50 amino acids of AID.
Conjugation:
Unconjugated
Alternative Names:
Activation-induced cytidine deaminase,AID,ARP2,CDA2,cytidine aminohydrolase,epididymis secretory protein Li 284,HEL-S-284,HIGM2,integrated into Burkitts lymphoma cell line Ramos,single-stranded DNA cytosine deaminase.
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).
