Ipaf antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human Ipaf. The immunogen is located within the last 50 amino acids of Ipaf.
Conjugation:
Unconjugated
Alternative Names:
AIFEC,CARD, LRR, and NACHT-containing protein,CARD12,caspase recruitment domain family, member 12,caspase recruitment domain-containing protein 12,CED-4-like protein Clan,CLAN,CLAN1,CLANA,CLANB,CLANC,CLAND,CLR2.1,FCAS4,Ice protease-activating factor,ICE-protease activating factor,IPAF,NLR family CARD domain-containing protein 4,NOD-like receptor C4,nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4.
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).
