SARM antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human SARM. The immunogen is located within amino acids 640 - 690 of SARM.
Conjugation:
Unconjugated
Alternative Names:
hSARM1,HsTIR,MyD88-5,NAD(+) hydrolase SARM1,NADase SARM1,NADP(+) hydrolase SARM1,SAM domain-containing protein 2,SAMD2,SARM,sterile alpha and Armadillo repeat protein,sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila,sterile alpha and TIR motif-containing protein 1,sterile alpha motif domain-containing protein 2,tir-1 homolog.
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
