TICAM2 Antibody
Catalog Number:
ASB-OAPB00234
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| Article Name: | TICAM2 Antibody |
| Biozol Catalog Number: | ASB-OAPB00234 |
| Supplier Catalog Number: | OAPB00234 |
| Alternative Catalog Number: | ASB-OAPB00234-0.1MG |
| Manufacturer: | Aviva |
| Host: | Rabbit |
| Category: | Proteine/Peptide |
| Application: | ELISA, IF, IHC-P, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | TIRP antibody was raised against a peptide corresponding to amino acids near the C-terminus of human TIRP. The immunogen is located within the last 50 amino acids of TIRP. |
| Conjugation: | Unconjugated |
| Alternative Names: | cytoplasmic adaptor,MyD88-4,NF-kappa-B-activating protein 502,putative NF-kappa-B-activating protein 502,TICAM2,TICAM-2,TIR domain-containing adapter molecule 2,TIRAP3,TIRP,TMED7-TICAM2 read-through transcript,toll/interleukin-1 receptor (TIR) domain-containing adapter protein,Toll/interleukin-1 receptor domain-containing protein,toll-like receptor adaptor protein 3,TRAM,TRAM adaptor with GOLD domain,TRIF-related adapter molecule,TRIF-related adaptor molecule. |
| Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1, signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB, however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. |
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