PIKE antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human PIKE. The immunogen is located within the last 50 amino acids of PIKE.
Conjugation:
Unconjugated
Alternative Names:
Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2,arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2,centaurin, gamma 1,Centaurin-gamma-1,CENTG1,GGAP2,GTP-binding and GTPase activating protein 2,GTP-binding and GTPase-activating protein 2,phosphatidylinositol 3-kinase enhancer,phosphoinositide 3-kinase enhancer,PIKE.
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
