Bax antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Bax. The immunogen is located within the first 50 amino acids of Bax.
Conjugation:
Unconjugated
Alternative Names:
apoptosis regulator BAX,Baxdelta2G9,Baxdelta2G9omega,Baxdelta2omega,BCL2 associated X protein,BCL2-associated X protein omega,bcl2-L-4,BCL2L4,bcl-2-like protein 4.
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
