UBC13 antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human UBC13. The immunogen is located within the last 50 amino acids of UBC13.
Conjugation:
Unconjugated
Alternative Names:
bendless-like ubiquitin conjugating enzyme,Bendless-like ubiquitin-conjugating enzyme,E2 ubiquitin-conjugating enzyme N,epididymis secretory protein Li 71,HEL-S-71,UBC13,UbcH13,UbcH-ben,UBCHBEN, UBC13,ubiquitin carrier protein N,ubiquitin conjugating enzyme E2N,ubiquitin-conjugating enzyme E2 N,ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13),ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast),ubiquitin-protein ligase N,yeast UBC13 homolog.
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical Lys-63-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the Lys-63-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate Lys-63-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
