Anti-BIM antibody (3405) was raised against a peptide corresponding to amino acids near the center of human BIM. The immunogen is located within amino acids 80-130 of BIM.
Conjugation:
Unconjugated
Alternative Names:
BAM,bcl-2 interacting mediator of cell death,bcl-2 interacting protein Bim,Bcl2-interacting mediator of cell death,BCL2-like 11 (apoptosis facilitator),bcl-2-like protein 11,bcl-2-related ovarian death agonist,BIM,BOD.
Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
