Cyclin O antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Cyclin O. The immunogen is located within the first 50 amino acids of Cyclin O.
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.
