Avian Influenza H5N1 Hemagglutinin (IN2) Antibody was raised against a synthetic peptide corresponding to 10 amino acids near the center of the Hemagglutinin protein. Efforts were made to use relatively conserved regions of the viral sequence as the antigen. The immunogen is located within amino acids 260 - 310 of Avian Influenza H5N1 Hemagglutinin (IN2) Antibody.
Conjugation:
Unconjugated
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Clonality:
Polyclonal
Concentration:
1 mg/ml
Form:
Liquid. Avian Influenza Hemagglutinin 4 Antibody is supplied in PBS containing 0.02% sodium azide.
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