CRTH2 antibody was raised against a 15 amino acid synthetic peptide from near the center of human CRTH2. The immunogen is located within amino acids 220 - 270 of CRTH2.
Conjugation:
Unconjugated
Alternative Names:
CD294,chemoattractant receptor homologous molecule expressed on T helper type 2 cells,chemoattractant receptor-homologous molecule expressed on TH2 cells,CRTH2,DL1R,DP2,GPR44,G-protein coupled receptor 44,prostaglandin D2 receptor 2,putative G-protein coupled receptor 44.
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
