NogoA antibody was raised against a 19 amino acid synthetic peptide from near the center of human NogoA. The immunogen is located within amino acids 200 - 250 of NogoA.
Conjugation:
Unconjugated
Alternative Names:
ASY,foocen,Human NogoA,My043 protein,Nbla00271,Nbla10545,neurite growth inhibitor 220,neurite outgrowth inhibitor,Neuroendocrine-specific protein,neuroendocrine-specific protein C homolog,NI220/250,NOGO,NSP,NSP-CL,reticulon 5,reticulon-4,Reticulon-5,RTN4-A,RTN4-B1,RTN4-B2,RTN4-C,RTN-X.
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977). Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).
