IEX1 antibody was raised against a 24 amino acid synthetic peptide near the center of human IEX1. The immunogen is located within amino acids 40 - 90 of IEX-1.
Conjugation:
Unconjugated
Alternative Names:
anti-death protein,DIF2,DIF-2,differentiation-dependent gene 2 protein,expressed in pancreatic carcinoma,GLY96,gly96, mouse, homolog of,IEX1,IEX-1,IEX-1L,immediate early protein GLY96,immediate early response 3 protein,immediately early gene X-1,PACAP-responsive gene 1 protein,PRG1,protein DIF-2,radiation-inducible immediate-early gene IEX-1.
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
