IGF1 ELISA Kit (Guinea pig )
Catalog Number:
ASB-OKCD01444
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| Article Name: | IGF1 ELISA Kit (Guinea pig ) |
| Biozol Catalog Number: | ASB-OKCD01444 |
| Supplier Catalog Number: | OKCD01444 |
| Alternative Catalog Number: | ASB-OKCD01444-96WELLS |
| Manufacturer: | Aviva |
| Category: | Kits/Assays |
| Application: | ELISA |
| Species Reactivity: | Guinea pig, Plant |
| Alternative Names: | IGF-I,insulin-like growth factor I,somatomedin. |
| The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity). |
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