TFRC ELISA Kit (Human)
Catalog Number:
ASB-OKCD01570
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| Article Name: | TFRC ELISA Kit (Human) |
| Biozol Catalog Number: | ASB-OKCD01570 |
| Supplier Catalog Number: | OKCD01570 |
| Alternative Catalog Number: | ASB-OKCD01570-96WELLS |
| Manufacturer: | Aviva |
| Category: | Kits/Assays |
| Application: | ELISA |
| Species Reactivity: | Human |
| Alternative Names: | CD71,IMD46,p90,T9,TFR,TFR1,TR,transferrin receptor protein 1,TRFR. |
| Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). |
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